Endocrine Abstracts

Transcriptional activity of androgen receptor (AR) is governed by androgenic ligands and (thought to be) fine-tuned by post-translational modifications, such as SUMOylation. We have utilized genome-wide tools to study in an unbiased fashion the role of SUMOylation in the regulation of AR-directed gene programs in prostate cancer cells. Our results show that the SUMOylation does not simply repress the AR activity, but the modification modulates the receptor activity in a target...

Covalent modifications offer an efficient and fast means to modulate protein function. They play a key role in the regulation of steroid receptor-dependent transcription by remodeling the chromatin structural proteins. Steroid receptor coregulator proteins, coactivators and corepressors, which function as signaling intermediates between receptors and chromatin or transcription machinery, often possess or recruit activities that catalyze covalent lysine modifications, such as a...